We are getting an error which is ClassNotFoundException when running on Android Studio 3.5.
This error occurs on API 21 or 22 device. Others don't.

My project configuration is here.
- AGP 3.5.0-beta01
- Using Kotlin
- Using Multidex
- Add package name suffix when debugging

I'm not sure but I find a solution to run the app. When adding `debuggable false ` to build.gradle, the app is running normally. But, we cannot debug with breakpoint.

Sorry, I cannot attach our project and cannot be public. If you want to more information, ask me anything.

Error log is here.

```
05-16 16:35:05.987 30050-30050/com.xxxx.yyyy.debug E/AndroidRuntime: FATAL EXCEPTION: main
Process: com.xxxx.yyyy.debug, PID: 30050
java.lang.RuntimeException: Unable to instantiate application com.xxxx.yyyy.ZZZZApplication: java.lang.ClassNotFoundException: Didn't find class "com.xxxx.yyyy.ZZZZApplication" on path: DexPathList[[zip file "/data/app/com.xxxx.yyyy.debug-1/base.apk"],nativeLibraryDirectories=[/vendor/lib, /system/lib]]
at android.app.LoadedApk.makeApplication(LoadedApk.java:563)
at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4491)
at android.app.ActivityThread.access$1500(ActivityThread.java:144)
at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1339)
at android.os.Handler.dispatchMessage(Handler.java:102)
at android.os.Looper.loop(Looper.java:135)
at android.app.ActivityThread.main(ActivityThread.java:5221)
at java.lang.reflect.Method.invoke(Native Method)
at java.lang.reflect.Method.invoke(Method.java:372)
at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:899)
at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:694)
Caused by: java.lang.ClassNotFoundException: Didn't find class "com.xxxx.yyyy.ZZZZApplication" on path: DexPathList[[zip file "/data/app/com.xxxx.yyyy.debug-1/base.apk"],nativeLibraryDirectories=[/vendor/lib, /system/lib]]
at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
at java.lang.ClassLoader.loadClass(ClassLoader.java:511)
at java.lang.ClassLoader.loadClass(ClassLoader.java:469)
at android.app.Instrumentation.newApplication(Instrumentation.java:979)
at android.app.LoadedApk.makeApplication(LoadedApk.java:558)
at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4491)
at android.app.ActivityThread.access$1500(ActivityThread.java:144)
at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1339)
at android.os.Handler.dispatchMessage(Handler.java:102)
at android.os.Looper.loop(Looper.java:135)
at android.app.ActivityThread.main(ActivityThread.java:5221)
at java.lang.reflect.Method.invoke(Native Method)
at java.lang.reflect.Method.invoke(Method.java:372)
at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:899)
at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:694)
Suppressed: java.lang.NoClassDefFoundError: com.xxxx.yyyy.ZZZZApplication
at dalvik.system.DexFile.defineClassNative(Native Method)
at dalvik.system.DexFile.defineClass(DexFile.java:226)
at dalvik.system.DexFile.loadClassBinaryName(DexFile.java:219)
at dalvik.system.DexPathList.findClass(DexPathList.java:321)
at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:54)
... 14 more
Suppressed: java.lang.ClassNotFoundException: com.xxxx.yyyy.ZZZZApplication
at java.lang.Class.classForName(Native Method)
at java.lang.BootClassLoader.findClass(ClassLoader.java:781)
at java.lang.BootClassLoader.loadClass(ClassLoader.java:841)
at java.lang.ClassLoader.loadClass(ClassLoader.java:504)
... 13 more
Caused by: java.lang.NoClassDefFoundError: Class not found using the boot class loader; no stack available
```

Build: AI-191.6707.61.35.5529924, 201905031752,

AI-191.6707.61.35.5529924, JRE 1.8.0_202-release-1483-b01x64 JetBrains s.r.o, OS Mac OS X(x86_64) v10.14.4, screens 1920x1080, 1440x900; Retina

AS: 3.5 Beta 1; Android Gradle Plugin: 3.5.0-beta01; Gradle: 5.4; NDK: from local.properties: 19.2.5345600, latest from SDK: 19.2.5345600; LLDB: LLDB 3.1 (revision: 3.1.4508709); CMake: from local.properties: (not specified), latest from SDK: 3.10.2, from PATH: (not found)

IMPORTANT: Please read https://developer.android.com/studio/report-bugs.html carefully and supply all required information.

Issue 132840182

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