Using various versions of R8 I can consistently reproduce this NullPointerException encountered while processing valid bytecode.

Building my project with AGP v4.0.1 (R8 v2.0.88) I get the following stack trace:
Caused by: java.lang.NullPointerException
at com.android.tools.r8.ir.optimize.g0.a(:52)
at com.android.tools.r8.ir.conversion.O.a(:486)
at com.android.tools.r8.ir.conversion.O.a(:417)
at com.android.tools.r8.ir.conversion.O.b(:53)
... 8 more

This error occurs during processing processing
Error in inputs/3.jar:kotlinx/coroutines/internal/MainDispatcherLoader.class at Lkotlinx/coroutines/internal/MainDispatcherLoader;loadMainDispatcher()Lkotlinx/coroutines/MainCoroutineDispatcher;

I have uploaded the compiled jars and a script for running r8 that will reproduce this issue.

https://drive.google.com/file/d/1uX9Ueb2W8TnQBw1v_JqFYUTllTtJqEXY/view?usp=sharing

I have reproduced this issue with various versions of r8 compiled from tags of https://r8.googlesource.com/r8
1.6.67
2.0.88 (with AGP v4.0.1)
2.1.38
2.2.6-dev

Please contact me if you need any further information.